Effects of Moquiniastrum polymorphum ssp floccosum ethnolic extract on colorectal carcinogenesis induced by 1,2-dimethylhydrazine
نویسندگان
چکیده
منابع مشابه
Moquiniastrum polymorphum subsp floccosum extract: screening for mutagenic and antimutagenic activity.
Moquiniastrum polymorphum subsp floccosum (Cabrera) G. Sancho is used in traditional Brazilian medicine to treat inflammation and infection, which is supported by scientific data. However, only one study has been conducted on the mutagenic activity of the extract, which has important safety implications. This study evaluated the mutagenic/antimutagenic activity of M. polymorphum ethanolic extra...
متن کاملThe dimethylhydrazine induced colorectal tumours in rat - experimental colorectal carcinogenesis
The beginnings of the first animal model appreciated for its macroscopic and histological similarity to human colorectal carcinoma (CRC) extend to 1963, when Laqueur discovered that rats fed cycasin, a plant product, developed intestinal cancer. The active substance was identified and soon a similar compound, methylazoxymethanol acetate (MAMA) was synthesized that was more effective than the na...
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15 صفحه اولBeef meat promotion of dimethylhydrazine-induced colorectal carcinogenesis biomarkers is suppressed by dietary calcium.
Red meat consumption is associated with increased risk of colorectal cancer. We have previously shown that haemin, Hb and red meat promote carcinogen-induced preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF) in rats. We have also shown that dietary Ca, antioxidant mix and olive oil inhibit haemin-induced ACF promotion, and normalize faecal lipoperoxides and cytotoxi...
متن کامل[Chemopreventive effects of 5-fluorouracil and lactoferrin on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine].
The present study was carried out to examine the chemopreventive effects of 5-fluorouracil (5-FU) and lactoferrin (LF) on goldfish intestinal carcinogenesis induced by 1,2-dimethylhydrazine (DMH). DMH was given to fish by intraperitoneal injection in a dosage of 15 mg/kg body weight once a week for 6 weeks. Eight weeks after the initial DMH injection, fish were randomly divided into 2 groups, c...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2017
ISSN: 1676-5680
DOI: 10.4238/gmr16019518